Description

1-Palmitoyl-2-Stearoyl-(10-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog, a critical tool for probing membrane dynamics and structure. Its value lies in the incorporation of a stable nitroxide radical (doxyl) at a specific position on the stearoyl chain, enabling advanced biophysical studies using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. This compound is essential for researchers and product developers in biophysics, pharmaceutical formulation, and membrane biochemistry who require precise molecular reporters to study lipid bilayer properties, protein-lipid interactions, and drug delivery system integrity.

Application

• Membrane Biophysics Research: As a spin probe for EPR spectroscopy to investigate membrane fluidity, phase transitions, and lateral organization in model lipid bilayers and vesicles.
• Lipid-Protein Interaction Studies: To study the binding, orientation, and conformational changes of membrane-associated proteins and peptides.
• Drug Delivery System Analysis: Used to characterize the stability, integrity, and release mechanisms of liposomal and nanoparticle-based delivery platforms.
• Oxidative Stress Modeling: The nitroxide group can serve as a reporter for local redox environments and free radical processes within membranes.
• Method Development & Validation: Employed as a standard or reference compound in the development of new EPR and other spectroscopic assays for lipid systems.
• Academic & Industrial R&D: Fundamental research in universities and applied research in pharmaceutical and biotechnology companies focused on membrane-targeted therapeutics.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(10-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	188004-25-3
Molecular Formula	C₄₅H₈₉NO₈P
Molecular Weight	827.16 g/mol
Synonyms	16:0-18:0(10-doxyl) PC; 1-Palmitoyl-2-stearoyl-(10-doxyl)-PC; 10-Doxyl PC (16:0-18:0); Phosphatidylcholine, 1-hexadecanoyl-2-(10-(4,4-dimethyl-3-oxazolidinyloxy)octadecanoyl)-sn-glycero-3-phospho-; Spin-labeled phosphatidylcholine; SLPC; Doxyl stearic acid-labeled PC; EPR probe lipid; Nitroxide-labeled phospholipid
EINECS	Contact for details

Quality Control

Every batch of 1-Palmitoyl-2-Stearoyl-(10-Doxyl)-Sn-Glycero-3-Phosphocholine is synthesized and purified under controlled conditions to ensure the highest standard of chemical purity and spin label integrity. Our quality assurance includes rigorous analytical testing via NMR, MS, and HPLC to confirm structure, purity, and the absence of unlabeled or degraded species. A comprehensive Certificate of Analysis (COA) detailing assay, identity, and impurity profiles is provided with each shipment to support your critical research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen). This compound is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (by area normalization)
Assay (EPR)	Active spin label content ≥ 90%
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.