Description

Fasudil Hydrochloride Hydrate is a potent and selective inhibitor of Rho-associated protein kinase (ROCK), a key enzyme involved in cellular signaling pathways. This compound is of significant value in pharmaceutical research and development, particularly for investigating cardiovascular and neurological disorders. It is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery and preclinical studies for conditions such as hypertension, cerebral vasospasm, and pulmonary arterial hypertension.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) in preclinical studies for cardiovascular and cerebrovascular diseases.
• ROCK Pathway Investigation: A key biochemical tool for studying the role of Rho-kinase in cellular processes like smooth muscle contraction, actin cytoskeleton organization, and cell migration.
• Neurological Disorder Research: Used in models to explore therapeutic potential for cerebral ischemia, stroke, and neurodegenerative conditions.
• Vascular Biology Studies: Applied in research targeting pulmonary arterial hypertension, angina, and other vascular disorders mediated by abnormal vascular tone.
• Cell Biology & Signal Transduction: Employed to elucidate mechanisms of cell proliferation, apoptosis, and inflammation.
• Formulation Development: Serves as the core component in the development of novel drug delivery systems and dosage forms.

Basic Information

Product Name	Fasudil Hydrochloride Hydrate
CAS No.	186694-02-0
Molecular Formula	C14H17N3O2S • HCl • xH2O
Molecular Weight	327.83 (Anhydrous base) / Contact for details (Hydrate)
Synonyms	HA-1077 Dihydrochloride; AT877; Fasudil HCl Hydrate; 5-Isoquinolinesulfonamide, 1-(5-isoquinolinylsulfonyl)homopiperazine, Hydrochloride, Hydrate; (1-(5-Isoquinolinesulfonyl)homopiperazine) Hydrochloride Hydrate; ERIL; Hydroxyfasudil (related metabolite); Rho-kinase Inhibitor HA-1077 Hydrochloride Hydrate
EINECS	Contact for details

Quality Control

Our Fasudil Hydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	As per hydrate form specification
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm
Related Substances (HPLC)	Total impurities <2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.