Description

1-(2-Trifluoromethoxy-Phenyl)-Piperazine is a high-purity, specialized piperazine derivative characterized by its trifluoromethoxy-substituted aromatic ring. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. It is primarily utilized by research institutions and chemical manufacturers in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of central nervous system (CNS) active compounds and other therapeutic agents.
• Agrochemical Research: Building block for developing new generation pesticides and herbicides with enhanced efficacy.
• Organic Synthesis: Versatile reagent for constructing complex heterocyclic structures and facilitating medicinal chemistry programs.
• Chemical Research & Development: Used in academic and industrial R&D for exploring structure-activity relationships (SAR) and new chemical entities.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers and advanced functional materials.

Basic Information

Product Name	1-(2-Trifluoromethoxy-Phenyl)-Piperazine
CAS No.	186386-95-8
Molecular Formula	C11H13F3N2O
Molecular Weight	246.23 g/mol
Synonyms	1-[2-(Trifluoromethoxy)phenyl]piperazine; 2-(Trifluoromethoxy)phenylpiperazine; 1-(2-Trifluoromethoxyphenyl)piperazine; 1-(2-(Trifluoromethoxy)phenyl)piperazine; 186386-95-8; TFMPP (context-specific); 2-Trifluoromethoxyphenylpiperazine
EINECS	Contact for details

Quality Control

Our 1-(2-Trifluoromethoxy-Phenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.