Description

Metreleptin is a recombinant analog of the human hormone leptin, a critical regulator of energy homeostasis and metabolism. This high-purity pharmaceutical ingredient is essential for addressing severe metabolic disorders associated with leptin deficiency. It is primarily utilized by the global biopharmaceutical industry for the formulation of advanced therapeutic solutions. Metreleptin CAS NO 186018-45-1 represents a key active pharmaceutical ingredient (API) for targeted metabolic therapies.

Application

• Primary Pharmaceutical Ingredient: Core API for the treatment of generalized lipodystrophy and congenital leptin deficiency.
• Metabolic Disorder Research: Critical reagent for preclinical and clinical studies investigating obesity, diabetes, and related metabolic syndromes.
• Biopharmaceutical Development: Used in the formulation and stability testing of injectable biologic drugs.
• Reference Standard: Serves as a high-purity standard for quality control and analytical method development in regulatory submissions.
• Cell Signaling Studies: Employed in biochemical research to study leptin receptor pathways and signal transduction mechanisms.

Basic Information

Product Name	Metreleptin
CAS No.	186018-45-1
Molecular Formula	C713H1135N193O211S8
Molecular Weight	Approx. 16,150 Da
Synonyms	Recombinant Methionyl Human Leptin; r-metHuLeptin; Leptin (human recombinant); Myalept® (brand name); OB protein; Leptin analog; Anti-Obesity Protein
EINECS	Contact for details

Quality Control

Our Metreleptin is manufactured under strict cGMP guidelines to ensure the highest standards of purity and consistency for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical quality attributes such as purity, identity, potency, and impurity profiles. We adhere to relevant pharmacopeial standards and our quality systems are designed to meet the stringent requirements of global regulatory bodies, including the FDA and EMA.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Potency (Bioassay)	90% - 110% of labeled activity
Endotoxin	< 1.0 EU/mg
Residual Moisture (KF)	≤ 3.0%
Related Proteins (HPLC)	Total related substances ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.