Description

Pyrazinecarboxamide, 3,4-Dihydro-n-Hydroxy-3-Oxo- (9Ci) is a specialized heterocyclic compound that serves as a key synthetic intermediate and pharmacophore in advanced research and development. Its unique structure, featuring a hydroxamic acid moiety fused to a dihydropyrazine ring, makes it valuable for modulating biological activity and chelating metal ions. This high-purity chemical is primarily sought by pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting metalloenzymes like histone deacetylases (HDACs) due to its hydroxamic acid group.
• Agrochemical Research: Used in developing new generations of fungicides and herbicides, where its heterocyclic core contributes to bioactivity and environmental specificity.
• Chemical Biology Probe: Acts as a scaffold for creating molecular probes to study enzyme function and signal transduction pathways in biological systems.
• Coordination Chemistry: Utilized as a ligand in the preparation of metal-organic complexes and catalysts for organic synthesis and material science applications.
• Material Science Precursor: Investigated for the development of advanced polymers and functional organic materials with specific electronic or binding properties.

Basic Information

Product Name	Pyrazinecarboxamide, 3,4-Dihydro-n-Hydroxy-3-Oxo- (9Ci)
CAS No.	185949-08-0
Molecular Formula	C5H5N3O3
Molecular Weight	155.11 g/mol
Synonyms	3,4-Dihydro-3-oxo-N-hydroxy-4-pyrazinecarboxamide; 4-Pyrazinecarboxamide, 3,4-dihydro-N-hydroxy-3-oxo-; N-Hydroxy-3,4-dihydro-3-oxopyrazine-4-carboxamide; 3-Oxo-3,4-dihydro-pyrazine-4-carboxylic acid hydroxyamide; 4-Carbamoyl-N-hydroxypyrazine-3-one; Hydroxypyrazinecarboxamide derivative; HDAC inhibitor intermediate; Pyrazine hydroxamic acid
EINECS	Contact for details

Quality Control

Our Pyrazinecarboxamide, 3,4-Dihydro-n-Hydroxy-3-Oxo- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.