Description

Rivoglitazone CAS NO 185428-18-6 is a high-potency thiazolidinedione-class compound that functions as a selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ). This mechanism is critical for enhancing insulin sensitivity and regulating glucose metabolism, making it a valuable pharmacological agent. It is primarily required by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions engaged in metabolic disease research and drug development.

Application

• Pharmaceutical Reference Standard: Serves as a primary chemical reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and research of novel antidiabetic medications targeting PPARγ receptors.
• Biochemical Research: A key tool compound for in vitro and in vivo studies investigating insulin resistance, adipogenesis, and type 2 diabetes pathways.
• Mechanism of Action Studies: Employed to elucidate the downstream signaling effects and gene regulation mediated by PPARγ activation.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology profiling during early-stage drug discovery.

Basic Information

Product Name	Rivoglitazone
CAS No.	185428-18-6
Molecular Formula	C21H21N3O4S
Molecular Weight	411.47 g/mol
Synonyms	CS-011; Rivoglitazone Hydrochloride (salt form); 5-[[4-[(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; (+)-Rivoglitazone; (2R)-5-({4-[(3R,6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
EINECS	Contact for details

Quality Control

Our Rivoglitazone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent standards for research use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.