Description

2,6-Bis[(4S,5S)-4-Methyl-5-Phenyl-2-Oxazolinyl]pyridine is a high-purity, chiral oxazoline-based ligand, a critical component in asymmetric synthesis and catalysis. Its precise stereochemistry and rigid structure make it invaluable for inducing high enantioselectivity in metal-catalyzed reactions, directly impacting the efficiency and cost of producing advanced intermediates. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance chiral auxiliaries to develop novel active ingredients and complex molecules.

Application

• As a chiral ligand in asymmetric catalysis, including hydrogenation, cyclopropanation, and Diels-Alder reactions.
• Key component in the synthesis of enantiomerically pure pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Utilized in the development of novel agrochemicals and specialty fine chemicals requiring specific stereochemistry.
• Employed in academic and industrial research for method development in organic and organometallic chemistry.
• Acts as a building block or precursor for more complex, multifunctional ligand systems.
• Used in the preparation of chiral metal-organic frameworks (MOFs) or materials with asymmetric catalytic properties.

Basic Information

Product Name	2,6-Bis[(4S,5S)-4-Methyl-5-Phenyl-2-Oxazolinyl]pyridine
CAS No.	185346-20-7
Molecular Formula	C26H24N4O2
Molecular Weight	424.50 g/mol
Synonyms	Pyridine, 2,6-bis[(4S,5S)-4-methyl-5-phenyl-2-oxazolinyl]-; (S,S)-2,6-Bis(4-methyl-5-phenyl-2-oxazolin-2-yl)pyridine; (S,S)-PyBOX; (S,S)-2,6-Bis(4-methyl-5-phenyl-4,5-dihydrooxazol-2-yl)pyridine; Chiral PyBOX Ligand; 2,6-Bis[(4S,5S)-4-methyl-5-phenyl-4,5-dihydrooxazol-2-yl]pyridine; 2,6-Bis(4-methyl-5-phenyl-2-oxazoliny)pyridine, (S,S)-form
EINECS	Contact for details

Quality Control

Our production of 2,6-Bis[(4S,5S)-4-Methyl-5-Phenyl-2-Oxazolinyl]pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.