Description

2-(4-Trifluoromethyl-Phenyl)-Piperazine is a high-purity, fluorinated piperazine derivative, a crucial building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and bioavailability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and psychiatric therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethylphenyl moiety.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized as a building block for developing molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(4-Trifluoromethyl-Phenyl)-Piperazine
CAS No.	185110-19-4
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	1-(4-(Trifluoromethyl)phenyl)piperazine; 4-(Trifluoromethyl)phenylpiperazine; 1-[4-(Trifluoromethyl)phenyl]piperazine; 4-(Piperazin-1-yl)benzotrifluoride; p-Trifluoromethylphenylpiperazine; 4-Trifluoromethyl-1-piperazinobenzene; 185110-19-4; TFMPP (context-dependent)
EINECS	Contact for details

Quality Control

Our 2-(4-Trifluoromethyl-Phenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under dry conditions to prevent degradation. Keep away from strong alkalis and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.