Description

Aminooxy-Peg2-Alcohol is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group and a terminal hydroxyl group. This compound is a critical building block in bioconjugation chemistry, enabling the site-specific attachment of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors for the development of advanced therapeutics, targeted drug delivery systems, and sensitive assay platforms.

Application

• Bioconjugation and PEGylation: Site-specific conjugation of peptides, proteins, antibodies, and oligonucleotides via oxime ligation with carbonyl-containing molecules (e.g., ketones, aldehydes).
• Antibody-Drug Conjugate (ADC) Development: Facilitating the construction of stable, homogeneous ADCs by linking cytotoxic payloads to monoclonal antibodies.
• Surface Functionalization: Modifying nanoparticles, biosensors, and microarray surfaces to introduce reactive handles for subsequent biomolecule immobilization.
• Crosslinking Reagent: Acting as a hydrophilic spacer in crosslinking applications to improve solubility and reduce immunogenicity of conjugated products.
• Polymer Chemistry: Serving as a functional initiator or monomer in the synthesis of tailored, functionalized PEG-based copolymers and hydrogels.
• Diagnostic Reagent Synthesis: Creating labeled probes and reagents for immunoassays, fluorescence in situ hybridization (FISH), and other diagnostic techniques.

Basic Information

Product Name	Aminooxy-Peg2-Alcohol
CAS No.	185022-12-2
Molecular Formula	C9H19NO5
Molecular Weight	221.25 g/mol
Synonyms	2-[2-(2-Aminooxyethoxy)ethoxy]ethanol; O-(2-Aminooxyethyl)-O'-(2-hydroxyethyl)triethylene glycol; Amino-PEG2-alcohol, aminooxy version; Aminooxy-functionalized PEG2 alcohol; Hydroxy-PEG2-aminooxy; 2,5,8,11-Tetraoxatridecan-13-ol, 12-aminooxy-; Heterobifunctional PEG linker, aminooxy-hydroxy
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg2-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and biopharmaceutical applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.