Description

5-[4-[2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)-2-Pyridyl]Ethoxy]-Benzyl]-2,4-Thiazolidinedione is a high-purity, non-racemic pharmaceutical intermediate and research chemical. This compound is of significant commercial interest due to its role as a key synthetic precursor in the development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced drug candidates targeting metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel thiazolidinedione-based drug candidates for research and development.
• Metabolic Disorder Research: Used in preclinical studies targeting pathways related to diabetes and insulin resistance.
• Chemical Synthesis: Serves as a versatile chiral synthon for constructing complex molecules in medicinal chemistry.
• Reference Standard: Employed as an analytical standard in quality control and method development for pharmaceutical manufacturing.
• Biochemical Research: Utilized in biochemical assays to study enzyme interactions and receptor binding activities.
• Process Development: Key material for scaling up and optimizing synthetic routes in pilot plant and commercial production.

Basic Information

Product Name	5-[4-[2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)-2-Pyridyl]Ethoxy]-Benzyl]-2,4-Thiazolidinedione
CAS No.	184766-66-3
Molecular Formula	C21H22N2O5S
Molecular Weight	414.48 g/mol
Synonyms	5-[4-[2-[5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-[5-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl]ethoxy]phenyl]methyl]thiazolidine-2,4-dione; (R)-5-(4-(2-(5-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; Rivoglitazone Intermediate; Rivoglitazone Related Compound; CS-011 Intermediate; TZD Derivative
EINECS	Contact for details

Quality Control

Our 5-[4-[2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)-2-Pyridyl]Ethoxy]-Benzyl]-2,4-Thiazolidinedione is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.