Description

4-(4-{4-[(3R,5R)-5-(2,4-Difluoro-Phenyl)-5-[1,2,4]Triazol-1-Ylmethyl-Tetrahydro-Furan-3-Ylmethoxy]-Phenyl}-Piperazin-1-Yl)-Phenylamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antifungal and other therapeutic research areas. It is essential for pharmaceutical R&D departments, process chemists, and manufacturers engaged in the development of next-generation small-molecule drugs.

Application

• Key Intermediate in Antifungal API Synthesis: Serves as a crucial building block in the research and production of triazole-based antifungal agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in developing and optimizing synthetic routes for complex chiral molecules under GMP or non-GMP conditions.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of proprietary drug candidates and novel chemical entities.

Basic Information

Product Name	4-(4-{4-[(3R,5R)-5-(2,4-Difluoro-Phenyl)-5-[1,2,4]Triazol-1-Ylmethyl-Tetrahydro-Furan-3-Ylmethoxy]-Phenyl}-Piperazin-1-Yl)-Phenylamine
CAS No.	184378-04-9
Molecular Formula	C30H32F2N6O2
Molecular Weight	546.61 g/mol
Synonyms	(3R,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]-3-({4-[4-(4-aminophenyl)piperazin-1-yl]phenoxy}methyl)oxolane; 4-[4-(4-{[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]aniline; UNII-8JQ5607E5S; 8JQ5607E5S; Auranofin Intermediate Derivative; Chiral Triazole-Furan-Piperazine Amine.
EINECS	Contact for details

Quality Control

Our 4-(4-{4-[(3R,5R)-5-(2,4-Difluoro-Phenyl)-5-[1,2,4]Triazol-1-Ylmethyl-Tetrahydro-Furan-3-Ylmethoxy]-Phenyl}-Piperazin-1-Yl)-Phenylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.