Description

1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazine is a high-purity, protected piperazine derivative of significant importance in modern synthetic organic chemistry. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for advanced drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• API Development: Used as a versatile building block for constructing novel active pharmaceutical ingredients with potential therapeutic applications.
• Medicinal Chemistry Research: Enables the exploration of new chemical entities (NCEs) in drug discovery programs, especially for creating libraries of fluorinated compounds.
• Peptidomimetic Synthesis: The Boc-protected piperazine moiety is valuable for creating peptidomimetics and modifying peptide backbones to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, complex specialty chemicals for various industrial applications.

Basic Information

Product Name	1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazine
CAS No.	184042-58-8
Molecular Formula	C11H21FN2O2
Molecular Weight	232.30 g/mol
Synonyms	1-(2-Fluoroethyl)-4-(tert-butoxycarbonyl)piperazine; 4-Boc-1-(2-fluoroethyl)piperazine; tert-Butyl 1-(2-fluoroethyl)piperazine-4-carboxylate; 1-(2-Fluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-1-(2-fluoroethyl)piperazine; Boc-1-(2-fluoroethyl)piperazine; 1-(2-Fluoroethyl)-4-Boc-piperazine; 184042-58-8
EINECS	Contact for details

Quality Control

Our 1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.