Description

Nepadutant CAS NO 183747-35-5 is a potent and selective neurokinin NK2 receptor antagonist. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and manufacturers in the life sciences sector for investigating and developing novel therapeutic agents for gastrointestinal and respiratory disorders.

Application

• Pharmaceutical Research & Development (R&D): A key tool compound for studying the role of neurokinin NK2 receptors in various physiological and pathophysiological processes.
• Preclinical Studies: Used in animal models to evaluate the efficacy and safety of NK2 receptor antagonism for potential therapeutic applications.
• Lead Compound Optimization: Serves as a reference molecule in medicinal chemistry programs aimed at developing new drug candidates targeting the NK2 receptor.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays to identify new NK2 receptor modulators.
• Academic Research: Used in university and institutional labs to explore neurokinin signaling pathways and their implications in disease.

Basic Information

Product Name	Nepadutant
CAS No.	183747-35-5
Molecular Formula	C33H49N7O6S
Molecular Weight	671.85 g/mol
Synonyms	MEN 11420; MEN-11420; (R)-[[2-[1-[2-[4-[(Aminosulfonyl)amino]phenyl]ethyl]-3-(1H-indol-3-yl)-2-methyl-1-oxo-1,2-dihydro-6-isoquinolinyl]acetyl]amino]-3-(1H-indol-3-yl)propanoic acid; Cyclo(L-Asp(OSO3H)-D-Trp-Lys(Z)-Thr-Phe); Nepadutant dihydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Nepadutant is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.