Description

n-4-Boc-2-Piperazineacetic Acid Methyl Ester is a high-purity, protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical versatile building block for constructing complex molecular architectures, particularly in pharmaceutical research. It is primarily used by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Combinatorial Library Synthesis: Employed in parallel and solid-phase synthesis to generate diverse compound libraries for high-throughput screening.
• Agrochemical Research: Utilized in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective deprotection, enabling multi-step synthetic sequences.

Basic Information

Product Name	n-4-Boc-2-Piperazineacetic Acid Methyl Ester
CAS No.	183742-33-8
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	1-Boc-2-(Methoxycarbonylmethyl)piperazine; Methyl 2-(4-(tert-Butoxycarbonyl)piperazin-2-yl)acetate; 2-(4-Boc-piperazin-2-yl)-acetic acid methyl ester; 1-N-Boc-2-Piperazineacetic Acid Methyl Ester; 4-Boc-2-Piperazineacetic Acid Methyl Ester; tert-Butyl 2-(methoxycarbonylmethyl)piperazine-1-carboxylate; Piperazine-1-carboxylic acid, 2-(carboxymethyl)-, 1,1-dimethylethyl ester, methyl ester
EINECS	Contact for details

Quality Control

Our n-4-Boc-2-Piperazineacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.