Description

4-Boc-1-Fmoc-2-Piperazinecarboxylic Acid is a high-purity, dual-protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical building block for the controlled construction of complex molecular architectures, particularly in peptide and medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams, CROs, and fine chemical manufacturers engaged in the development of novel therapeutics and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential introduction of piperazine moieties into peptide backbones.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing constrained heterocyclic scaffolds.
• Combinatorial Chemistry: Serves as a versatile building block for generating diverse chemical libraries for high-throughput screening.
• Protease Inhibitor Development: Employed in the synthesis of potential inhibitors targeting various protease enzymes.
• Linker Chemistry: Useful in the construction of chemical linkers for bioconjugation and prodrug strategies.
• Academic & Industrial Research: A valuable reagent for synthetic methodology development and exploring new chemical space in drug discovery programs.

Basic Information

Product Name	4-Boc-1-Fmoc-2-Piperazinecarboxylic Acid
CAS No.	183742-23-6
Molecular Formula	C25H28N2O6
Molecular Weight	452.50 g/mol
Synonyms	1-Fmoc-4-Boc-piperazine-2-carboxylic acid; 2-Piperazinecarboxylic acid, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-(1,1-dimethylethoxy)carbonyl]-; 4-(tert-Butoxycarbonyl)-1-[(9-fluorenylmethoxy)carbonyl]piperazine-2-carboxylic acid; Fmoc-Boc-piperazine-2-carboxylic acid; Boc-Fmoc-Pip-OH; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid; (2R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid; N-α-Fmoc-N'-δ-Boc-2-piperazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Boc-1-Fmoc-2-Piperazinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.