Description

1-T-Boc-Piperidine-4-Spiro-5'-Hydantoin is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic hydantoin scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting protease inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Peptidomimetic Synthesis: The spirocyclic hydantoin core is valuable for creating constrained peptide analogs and peptidomimetics.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against various disease targets.
• API Development: Serves as a precursor in the development route of potential Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	1-T-Boc-Piperidine-4-Spiro-5'-Hydantoin
CAS No.	183673-70-3
Molecular Formula	C13H21N3O4
Molecular Weight	283.33 g/mol
Synonyms	1-(tert-Butoxycarbonyl)piperidine-4-spiro-5'-hydantoin; tert-Butyl 4-(2,4-dioxoimidazolidin-3-yl)piperidine-1-carboxylate; 1-Boc-4-spirohydantoinpiperidine; 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)imidazolidine-2,4-dione; Piperidine-4-spiro-5'-hydantoin, 1-Boc-protected; 1-N-Boc-4-spiro-5'-hydantoinpiperidine; 1-tert-Butyl 4-(2,4-dioxoimidazolidin-3-yl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-T-Boc-Piperidine-4-Spiro-5'-Hydantoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.