Description

1-n-Boc-4-(3-Ethoxycarbonylmethyl-4-Oxo-3,4-Dihydro-Quinazolin-6-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone-piperazine class of compounds. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapy research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel quinazolinone-based kinase inhibitors for cancer therapy.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Employed in university and institutional labs for biochemical and pharmacological studies targeting specific disease pathways.
• Proteolysis-Targeting Chimera (PROTAC) Development: Potential use as a linker or component in the design of bifunctional degraders.

Basic Information

Product Name	1-n-Boc-4-(3-Ethoxycarbonylmethyl-4-Oxo-3,4-Dihydro-Quinazolin-6-Yl)Piperazine
CAS No.	183622-37-9
Molecular Formula	C22H28N4O5
Molecular Weight	428.48 g/mol
Synonyms	1-Boc-4-(3-(ethoxycarbonylmethyl)-4-oxo-3,4-dihydroquinazolin-6-yl)piperazine; tert-Butyl 4-(3-(ethoxycarbonylmethyl)-4-oxo-3,4-dihydroquinazolin-6-yl)piperazine-1-carboxylate; 6-(4-Boc-piperazin-1-yl)-3-(ethoxycarbonylmethyl)quinazolin-4(3H)-one; 1-(tert-Butoxycarbonyl)-4-[3-(carbethoxymethyl)-4-oxo-3,4-dihydro-6-quinazolinyl]piperazine; BOC-Piperazine-Quinazolinone Derivative; CAS 183622-37-9.
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(3-Ethoxycarbonylmethyl-4-Oxo-3,4-Dihydro-Quinazolin-6-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.