Description

1-n-Boc-4-(3-Carboxy-4-Nitrophenyl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine core with both carboxylic acid and nitro functional groups. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with targeted biological activity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing novel drug candidates, particularly in areas like kinase inhibitors and GPCR-targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce the piperazine moiety and modify physicochemical properties of drug-like molecules.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying enzyme function and signal transduction pathways due to its versatile reactive handles.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) specializing in complex, multi-step organic synthesis.

Basic Information

Product Name	1-n-Boc-4-(3-Carboxy-4-Nitrophenyl)Piperazine
CAS No.	183622-36-8
Molecular Formula	C₁₇H₂₁N₃O₆
Molecular Weight	363.37 g/mol
Synonyms	1-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine; tert-Butyl 4-(3-carboxy-4-nitrophenyl)piperazine-1-carboxylate; 4-Nitro-3-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoic Acid; 1-(tert-Butoxycarbonyl)-4-(3-carboxy-4-nitrophenyl)piperazine; 3-(4-Boc-piperazin-1-yl)-4-nitrobenzoic acid; 4-Nitro-3-(1-piperazinyl)benzoic acid 1-Boc derivative; BOC-4-(3-COOH-4-NO2-Ph)piperazine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Every batch is characterized and controlled using modern analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results. We adhere to cGMP principles where applicable to support our customers' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.