Description

3-Carboxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the orthogonal protection of the piperazine nitrogen and carboxylic acid functionalities, enabling precise, sequential reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of piperazine-based drug candidates, including protease inhibitors, kinase inhibitors, and GPCR modulators.
• Peptidomimetics Synthesis: Used to introduce constrained, functionalized piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in asymmetric catalysis or metal-organic frameworks (MOFs).
• Agrochemical Research: Building block for novel herbicides, fungicides, and insecticides that incorporate the piperazine pharmacophore.
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke synthesis projects requiring protected bifunctional intermediates.
• Academic Research: Used in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Item	Details
Product Name	3-Carboxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	183591-72-2
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	1-Boc-3-(carboxymethyl)piperazine; tert-Butyl 3-(carboxymethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(carboxymethyl)piperazine; 3-Carboxymethyl-1-Boc-piperazine; 1-N-Boc-3-piperazineacetic acid; Piperazine-1-carboxylic acid, 3-(carboxymethyl)-, 1,1-dimethylethyl ester; 3-(Carboxymethyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Carboxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance in cGMP and ISO 9001 environments for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.