Description

(17R,5Z,8Z,11Z,14Z)-17-Hydroxy-5,8,11,14-Eicosatetraenoic Acid is a specialized eicosanoid derivative, a key intermediate in the biosynthesis of resolvins and other pro-resolving lipid mediators. This compound matters for its critical role in advanced biochemical research focused on inflammation resolution pathways and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions conducting cutting-edge research in immunology, lipidomics, and drug discovery.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the identification and quantification of lipid mediators in complex biological samples via LC-MS/MS.
• Drug Discovery & Development: Serves as a crucial synthetic intermediate or a biological tool compound in the development of novel anti-inflammatory and pro-resolving therapeutics.
• Cell Signaling Studies: Employed in in vitro and ex vivo studies to investigate the specific roles of 17-Hydroxy series eicosatetraenoic acids in cellular signaling cascades.
• Metabolic Pathway Analysis: Essential for tracing and understanding the metabolic fate of arachidonic acid derivatives and the biosynthesis of specialized pro-resolving mediators (SPMs).
• Enzyme Activity Assays: Acts as a substrate or product in assays designed to measure the activity of key enzymes like cytochrome P450s or lipoxygenases involved in eicosanoid metabolism.

Basic Information

Item	Detail
Product Name	(17R,5Z,8Z,11Z,14Z)-17-Hydroxy-5,8,11,14-Eicosatetraenoic Acid
CAS No.	183509-24-2
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	17(R)-HETE; 17(R)-Hydroxyeicosatetraenoic Acid; (17R)-HETE; 17R-HETE; 17(R)-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; 17R-Hydroxyarachidonic Acid; 17(R)-Hydroxyarachidonic Acid
EINECS	Contact for details

Quality Control

Our (17R,5Z,8Z,11Z,14Z)-17-Hydroxy-5,8,11,14-Eicosatetraenoic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. All batches are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Isomeric Purity (Chiral HPLC)	≥ 98% 17(R) enantiomer
Solubility	Soluble in ethanol, DMSO, dimethyl formamide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.