Description

5-(4-tert-Butoxycarbonyl-2-Piperazinyl)Benzofuran-2-Carboxamide is a high-purity, advanced pharmaceutical intermediate featuring a benzofuran core linked to a protected piperazine moiety. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged scaffold.
• Protease Inhibitor Development: Serves as a precursor in the design and synthesis of molecules targeting specific protease enzymes.
• Kinase Inhibitor Synthesis: Employed in the construction of complex heterocyclic cores for potential kinase inhibitor candidates.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis Projects: A critical starting material for contract manufacturing organizations (CMOs) producing bespoke APIs for clinical trials.

Basic Information

Product Name	5-(4-tert-Butoxycarbonyl-2-Piperazinyl)Benzofuran-2-Carboxamide
CAS No.	183288-44-0
Molecular Formula	C18H23N3O4
Molecular Weight	345.39 g/mol
Synonyms	5-(4-Boc-2-piperazinyl)benzofuran-2-carboxamide; 2-Benzofurancarboxamide, 5-[4-[(1,1-dimethylethoxy)carbonyl]-2-piperazinyl]-; 5-(4-(tert-Butoxycarbonyl)piperazin-2-yl)benzofuran-2-carboxamide; tert-Butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate; BOC-Piperazinyl-Benzofuran-Carboxamide; 183288-44-0; 5-(4-Boc-piperazin-2-yl)-1-benzofuran-2-carboxamide
EINECS	Contact for details

Quality Control

Our 5-(4-tert-Butoxycarbonyl-2-Piperazinyl)Benzofuran-2-Carboxamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.