Description

4-(4-Nitrophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester CAS NO 182618-86-6 is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a versatile and reactive intermediate to construct complex nitrogen-containing heterocycles. It is primarily utilized in pharmaceutical R&D for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities, making it a key material for medicinal chemists and process development scientists.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the piperazine scaffold.
• Process Chemistry Development: Serves as a starting material for scaling up the production of complex molecules under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Synthesis: Used as an intermediate in the development of novel herbicides, fungicides, and insecticides.
• Material Science: Potential monomer or precursor for specialty polymers and advanced functional materials.

Basic Information

Product Name	4-(4-Nitrophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	182618-86-6
Molecular Formula	C15H21N3O4
Molecular Weight	307.35 g/mol
Synonyms	1-Boc-4-(4-nitrophenyl)piperazine; tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate; 4-(4-Nitrophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(4-nitrophenyl)piperazine; N-Boc-4-(4-nitrophenyl)piperazine; BOC-4-(4-Nitrophenyl)piperazine; 182618-86-6; 4-(4-Nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(4-Nitrophenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.