Description

1,4-Bis(n-Boc)Piperazine-2-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing piperazine or constrained peptide motifs.
• Peptidomimetic Synthesis: Used to introduce protected piperazine-2-carboxylic acid units into peptide backbones to create novel peptidomimetics with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry: Serves as a versatile scaffold in solid-phase and solution-phase library synthesis for high-throughput screening and drug discovery.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) groups provide orthogonal protection for the piperazine nitrogen atoms, enabling selective deprotection and sequential functionalization in multi-step syntheses.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to synthesize labeled or tagged molecules for studying biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	1,4-Bis(n-Boc)Piperazine-2-Carboxylic Acid
CAS No.	181955-79-3
Molecular Formula	C16H28N2O6
Molecular Weight	344.41 g/mol
Synonyms	1,4-Bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid; 2-Carboxy-1,4-bis(tert-butoxycarbonyl)piperazine; 1,4-Di-Boc-piperazine-2-carboxylic acid; (2S)-1,4-Bis[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid (for S-enantiomer); (2R)-1,4-Bis[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid (for R-enantiomer); 1,4-Bis(Boc)piperazine-2-carboxylic acid; Boc-Pip(2-COOH)-Boc; 1,4-Di-tert-butyl 2-(carboxymethyl) piperazine-1,4-dicarboxylate (alternative representation)
EINECS	Contact for details

Quality Control

Our 1,4-Bis(n-Boc)Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess (where applicable), and comprehensive identification and impurity profiling. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.