Description

2-(1-Piperazinyl)-Benzoic Acid Ethyl Ester is a versatile piperazine derivative and a key synthetic intermediate in organic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of various drug candidates, particularly those targeting the central nervous system (CNS).
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, leveraging the piperazine moiety for biological activity.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and other specialty chemicals requiring a functionalized benzoate structure.
• Research & Development: Employed in academic and industrial labs for method development, structure-activity relationship (SAR) studies, and library synthesis for high-throughput screening.
• Ligand and Catalyst Preparation: The nitrogen atoms in the piperazine ring can be utilized to create chelating ligands for metal catalysts or as part of organocatalysts.

Basic Information

Product Name	2-(1-Piperazinyl)-Benzoic Acid Ethyl Ester
CAS No.	180417-98-5
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	Ethyl 2-(piperazin-1-yl)benzoate; 2-Piperazin-1-yl-benzoic acid ethyl ester; Benzoic acid, 2-(1-piperazinyl)-, ethyl ester; Ethyl 2-(1-piperazinyl)benzoate; 1-(2-Ethoxycarbonylphenyl)piperazine; Ethyl o-piperazinobenzoate
EINECS	Contact for details

Quality Control

Our 2-(1-Piperazinyl)-Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to supply chain reliability and documentation transparency supports your regulatory and process validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.