Description

4-(4-(Trifluoromethoxy)Phenyl)Piperidine is a high-value, functionalized piperidine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethoxy-substituted aromatic ring, imparts desirable physicochemical properties for the development of novel active compounds. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of central nervous system (CNS) active drugs, potential enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for constructing molecular probes to study biological pathways and protein interactions in R&D settings.

Basic Information

Product Name	4-(4-(Trifluoromethoxy)Phenyl)Piperidine
CAS No.	180160-91-2
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	4-[4-(Trifluoromethoxy)phenyl]piperidine; 1-[4-(Trifluoromethoxy)phenyl]-4-piperidine; 4-(4-Trifluoromethoxyphenyl)piperidine; 4-Piperidin-4-ylphenyl trifluoromethyl ether; 180160-91-2; 4-(α,α,α-Trifluoro-p-tolyloxy)piperidine
EINECS	Contact for details

Quality Control

Every batch of 4-(4-(Trifluoromethoxy)Phenyl)Piperidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.