Description

1-[2-(Trifluoromethyl)Benzoyl]Piperazine is a high-value, fluorinated piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs). Pharmaceutical, agrochemical, and specialty chemical manufacturers rely on this high-purity intermediate for its role in constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Biochemical Tool Compound: Used in life sciences research as a probe or inhibitor to study specific biochemical pathways and receptor interactions.

Basic Information

Product Name	1-[2-(Trifluoromethyl)Benzoyl]Piperazine
CAS No.	179534-78-2
Molecular Formula	C12H13F3N2O
Molecular Weight	258.24 g/mol
Synonyms	2-(Trifluoromethyl)benzoylpiperazine; 1-[(2-Trifluoromethyl)benzoyl]piperazine; α,α,α-Trifluoro-o-toluoylpiperazine; N-(2-Trifluoromethylbenzoyl)piperazine; Piperazine, 1-[(2-(trifluoromethyl)phenyl)carbonyl]-; 2-(Trifluoromethyl)benzoic acid piperazide
EINECS	Contact for details

Quality Control

Our 1-[2-(Trifluoromethyl)Benzoyl]Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.