Description

1-(2,5-Difluorobenzyl)Piperazine 97 is a high-purity, functionalized piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where its difluorobenzyl moiety offers unique electronic and steric properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Employed in the synthesis of monomers or additives for advanced polymers and functional materials.
• Chemical Biology Probes: Useful for constructing molecular probes and tool compounds for biochemical and pharmacological research.
• Custom Synthesis Building Block: Provides a versatile scaffold for contract research organizations (CROs) and custom synthesis houses to create bespoke molecules for clients.

Basic Information

Product Name	1-(2,5-Difluorobenzyl)Piperazine 97
CAS No.	179334-18-0
Molecular Formula	C11H14F2N2
Molecular Weight	212.24 g/mol
Synonyms	1-[(2,5-Difluorophenyl)methyl]piperazine; N-[(2,5-Difluorophenyl)methyl]piperazine; 2,5-Difluoro-α-(piperazin-1-ylmethyl)benzene; 1-(2,5-Difluorobenzyl)piperazine; Piperazine, 1-[(2,5-difluorophenyl)methyl]-; 179334-18-0; (2,5-Difluorobenzyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(2,5-Difluorobenzyl)Piperazine 97 is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure it meets the declared purity and impurity profile specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and residual solvent content is provided with each shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.