Description

tert-Butyl 4-[2-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperazine and benzyl alcohol derivative structure. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. Pharmaceutical R&D teams, process chemists, and fine chemical manufacturers need this material for developing and scaling up novel drug candidates with precision and reliability.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, particularly those targeting neurological pathways.
• API Development: Serves as a crucial precursor in the research and process development of new Active Pharmaceutical Ingredients (APIs).
• Chemical Synthesis Building Block: Utilized in medicinal chemistry for constructing piperazine and substituted phenyl moieties in novel chemical entities.
• Process Chemistry & Scale-Up: Employed in pilot plant and commercial-scale manufacturing under current Good Manufacturing Practice (cGMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic & Industrial Research: Used in research laboratories for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Item	Detail
Product Name	tert-Butyl 4-[2-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	179250-28-3
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	1-Boc-4-(2-Hydroxymethylphenyl)piperazine; tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperazine-1-carboxylate; 4-(2-Hydroxymethylphenyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-(hydroxymethyl)phenyl)piperazine; 179250-28-3; BOC-4-(2-Hydroxymethylphenyl)piperazine; N-Boc-4-(2-Hydroxymethylphenyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[2-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, ensuring traceability and documentation for regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.