Description

tert-Butyl 4-(2-Cyanophenyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a cyano-substituted phenyl group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological receptors.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Particularly relevant for constructing molecules intended to interact with serotonin, dopamine, or other neurotransmitter systems.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production of investigational drugs.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	tert-Butyl 4-(2-Cyanophenyl)Piperazine-1-Carboxylate
CAS No.	179250-25-0
Molecular Formula	C16H21N3O2
Molecular Weight	287.36 g/mol
Synonyms	1-Boc-4-(2-Cyanophenyl)piperazine; 4-(2-Cyanophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2-cyanophenyl)piperazine-1-carboxylate; 2-(4-Boc-piperazin-1-yl)benzonitrile; 1-(tert-Butoxycarbonyl)-4-(2-cyanophenyl)piperazine; Boc-2-Cyanophenylpiperazine; N-Boc-4-(2-cyanophenyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Cyanophenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development with material that meets the stringent requirements for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.