Description

(3Z)-3-[2-(2,4-Dimethylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2- One is a high-purity, non-racemic chiral piperazinone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex, biologically active molecules with precise stereochemical control, which is essential for modern drug discovery and development. This compound is primarily needed by research institutions and pharmaceutical manufacturers focused on creating novel therapeutics, particularly in the areas of central nervous system (CNS) agents and receptor-targeted small molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting neurological pathways.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Employed as a chiral scaffold or precursor in stereoselective synthesis to create enantiomerically pure compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and reaction mechanisms.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	(3Z)-3-[2-(2,4-Dimethylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2- One
CAS No.	178408-23-6
Molecular Formula	C20H20N2O2
Molecular Weight	320.39 g/mol
Synonyms	(3Z)-3-[(2,4-Dimethylphenyl)(oxo)methylidene]-1-phenylpiperazin-2-one; 1-Phenyl-3-[(Z)-2-oxo-2-(2,4-dimethylphenyl)ethylidene]piperazin-2-one; (Z)-3-(2-(2,4-Dimethylphenyl)-2-oxoethylidene)-1-phenylpiperazin-2-one; 178408-23-6; (3Z)-3-[2-(2,4-Dimethylphenyl)-2-oxoethylidene]-1-phenyl-2-piperazinone; (Z)-3-(2-(2,4-Dimethylphenyl)-2-oxoethylidene)-1-phenyl-2-piperazinone
EINECS	Contact for details

Quality Control

Our (3Z)-3-[2-(2,4-Dimethylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2- One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (Z-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.