Description

(3Z)-3-[2-(4-Methylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2-One is a high-purity, synthetic organic compound belonging to the piperazinone class, serving as a critical advanced intermediate in pharmaceutical research and development. Its precise molecular architecture makes it a valuable building block for synthesizing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of lead compounds.
• Process Chemistry: Serves as a building block for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	(3Z)-3-[2-(4-Methylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2-One
CAS No.	178408-22-5
Molecular Formula	C19H18N2O2
Molecular Weight	306.36 g/mol
Synonyms	(Z)-3-(2-(4-Methylphenyl)-2-oxoethylidene)-1-phenylpiperazin-2-one; 3-[(Z)-2-(4-Methylphenyl)-2-oxoethylidene]-1-phenylpiperazin-2-one; 1-Phenyl-3-[(Z)-2-(p-tolyl)-2-oxoethylidene]piperazin-2-one; (3Z)-3-[2-(4-Methylphenyl)-2-oxoethylidene]-1-phenyl-2-piperazinone; 178408-22-5; Piperazin-2-one derivative
EINECS	Contact for details

Quality Control

Our (3Z)-3-[2-(4-Methylphenyl)-2-Oxo-Ethylidene]-1-Phenyl-Piperazin-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.