Description

tert-Butyl 4-acetylpiperazine-1-carboxylate is a versatile and high-purity pharmaceutical intermediate, primarily used as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in providing a protected piperazine scaffold, which is crucial for introducing specific pharmacophores and modulating the physicochemical properties of target drug molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those working on central nervous system (CNS) agents, kinase inhibitors, and other novel therapeutic entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry research and development.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperazine core.
• CNS Drug Development: Serves as a precursor for compounds targeting neurological disorders, such as antipsychotics, antidepressants, and cognitive enhancers.
• Kinase Inhibitor Scaffold: Employed in the construction of kinase inhibitor libraries for oncology and anti-inflammatory drug discovery programs.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	tert-Butyl 4-Acetylpiperazine-1-Carboxylate
CAS No.	178312-59-9
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	1-Boc-4-acetylpiperazine; 4-Acetyl-1-Boc-piperazine; tert-Butyl 4-acetyl-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-acetylpiperazine; 1-Boc-4-acetylpiperazine; N-Boc-4-acetylpiperazine; 4-Acetylpiperazine-1-carboxylic acid tert-butyl ester; Piperazine-1-carboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-acetylpiperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture uptake. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.