Description

3-[4-(Methylsulfonyl)-1-Piperazinyl]-1-Azetidinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and inflammatory pathways. It is primarily sought by pharmaceutical R&D departments, process development chemists, and fine chemical manufacturers engaged in innovative drug development programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Process Chemistry & Scale-Up: Serves as a defined starting material for optimizing and scaling API manufacturing routes under GMP conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Bioconjugation & Probe Development: The reactive functional groups make it suitable for creating chemical probes for biochemical and pharmacological studies.

Basic Information

Product Name	3-[4-(Methylsulfonyl)-1-Piperazinyl]-1-Azetidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	178312-23-7
Molecular Formula	C13H25N3O4S
Molecular Weight	319.42 g/mol
Synonyms	tert-Butyl 3-[4-(methylsulfonyl)piperazin-1-yl]azetidine-1-carboxylate; 1-Boc-3-[4-(Methylsulfonyl)piperazin-1-yl]azetidine; 1-(tert-Butoxycarbonyl)-3-[4-(methylsulfonyl)-1-piperazinyl]azetidine; 3-(4-Methanesulfonyl-piperazin-1-yl)-azetidine-1-carboxylic acid tert-butyl ester; BOC-3-(4-Methylsulfonylpiperazinyl)azetidine; Azetidine-1-carboxylic acid, 3-[4-(methylsulfonyl)-1-piperazinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-[4-(Methylsulfonyl)-1-Piperazinyl]-1-Azetidinecarboxylic Acid 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All materials are fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.