Description

1-(3-Azetidinyl)-4-(1,1-Dimethylethoxy)-Piperidine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 178312-03-3. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a defined stereochemical center for precise molecular construction. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery pipelines.

Application

This specialized intermediate serves as a key precursor in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and scale-up phases for creating new therapeutic molecules.
• Neurological & CNS Drug Research: Its structural features make it valuable for developing compounds targeting neurological pathways.
• Process Chemistry & Route Scouting: Employed by chemists to develop and optimize scalable synthetic routes for complex molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and development services.
• Academic & Industrial R&D: Used in laboratories for exploratory chemistry and proof-of-concept studies.

Basic Information

Product Name	1-(3-Azetidinyl)-4-(1,1-Dimethylethoxy)-Piperidine Dihydrochloride
CAS No.	178312-03-3
Molecular Formula	C13H27Cl2N2O
Molecular Weight	295.27 g/mol
Synonyms	1-(Azetidin-3-yl)-4-(tert-butoxy)piperidine dihydrochloride; 4-(tert-Butoxy)-1-(3-azetidinyl)piperidine dihydrochloride; tert-Butyl 4-(3-azetidinyl)-1-piperidinecarboxylate dihydrochloride; 1-(3-Azetidinyl)-4-(tert-butoxy)piperidine dihydrochloride; 1-(Azetidin-3-yl)-4-(tert-butoxy)piperidine hydrochloride (1:2); 4-(tert-Butoxy)-1-(azetidin-3-yl)piperidine dihydrochloride
EINECS	Contact for details

Quality Control

Our production of 1-(3-Azetidinyl)-4-(1,1-Dimethylethoxy)-Piperidine Dihydrochloride adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the material should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.