Description

1-Boc-4-[(2-Methylphenyl)Methyl]-4-Piperidinecarboxylic Acid is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with precise stereochemistry and functional group compatibility. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), drug candidates, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to introduce constrained, substituted piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Employed in the development of advanced herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Chemical Biology Probes: Utilized to create tagged or modified small molecules for target identification and mechanism-of-action studies.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	1-Boc-4-[(2-Methylphenyl)Methyl]-4-Piperidinecarboxylic Acid
CAS No.	177990-35-1
Molecular Formula	C19H27NO4
Molecular Weight	333.43 g/mol
Synonyms	4-[(2-Methylbenzyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2-methylbenzyl)-4-carboxypiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-methylbenzyl)piperidine-4-carboxylic acid; 1-Boc-4-(2-methylbenzyl)piperidine-4-carboxylic acid; BOC-Pip(2-Me-Bzl)-4-COOH; N-Boc-4-(o-methylbenzyl)isonipecotic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[(2-Methylphenyl)Methyl]-4-Piperidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring research-grade to cGMP standards for preclinical and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.