Description

n-(1-Azabicyalo[2,2,2]Oct-3S-Yl)-1,2,3,4-Tetrahydronaphthalen-1S-Ylcarboxamine is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, where precise molecular architecture and consistent quality are paramount for successful clinical outcomes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent receptor antagonists and modulators.
• Neurological Research: Used in the development of compounds for studying and treating conditions related to specific neurotransmitter systems.
• Cardiovascular Drug Development: Serves as a precursor in creating candidates for hypertension and related disorders.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Academic & Contract Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	n-(1-Azabicyalo[2,2,2]Oct-3S-Yl)-1,2,3,4-Tetrahydronaphthalen-1S-Ylcarboxamine
CAS No.	177793-81-6
Molecular Formula	C18H26N2O
Molecular Weight	286.42 g/mol
Synonyms	(3S)-3-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]carbamoyl]-1-azabicyclo[2.2.2]octane; (3S)-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1-azabicyclo[2.2.2]octane-3-carboxamide; 1-Azabicyclo[2.2.2]octane-3-carboxamide, N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (3S)-; ABT-089 Intermediate; Stereoisomer of PNU-282987; Chiral Quinuclidine-Tetralin Carboxamide
EINECS	Contact for details

Quality Control

Our n-(1-Azabicyalo[2,2,2]Oct-3S-Yl)-1,2,3,4-Tetrahydronaphthalen-1S-Ylcarboxamine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive identification and assay methods, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.