Description

H2N-Peg7-Ch2Cooh CAS NO 177580-10-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a carboxylic acid group at the other, connected by a flexible heptaethylene glycol spacer. This bifunctionality is critical for creating stable, water-soluble conjugates and crosslinks between diverse biomolecules and surfaces. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotech industries, enabling applications in drug delivery, bioconjugation, and surface modification.

Application

• Bioconjugation and Linker Chemistry: Used as a heterobifunctional crosslinker to covalently couple peptides, proteins, or antibodies to other molecules, nanoparticles, or solid supports.
• PEGylation Reagent: Serves as a functionalized PEG spacer to introduce amine-reactive or carboxyl-reactive sites for modifying therapeutic proteins, enhancing solubility and stability.
• Drug Delivery Systems: Incorporated into the design of prodrugs, antibody-drug conjugates (ADCs), and polymeric micelles to improve pharmacokinetics and target specificity.
• Surface Functionalization: Applied to modify the surface of biosensors, diagnostic chips, and medical devices to create bio-inert or specifically reactive coatings.
• Hydrogel Formation: Acts as a macromonomer in the synthesis of hydrogels for tissue engineering and controlled release applications.
• Material Science: Utilized to create PEG-based block copolymers and functional materials with tailored interfacial properties.

Basic Information

Product Name	H2N-Peg7-Ch2Cooh
CAS No.	177580-10-8
Molecular Formula	C19H39NO10
Molecular Weight	465.52 g/mol
Synonyms	8-Amino-3,6-dioxaoctanoic acid, 17-[(2-carboxyethyl)oxy]-; 2-[2-[2-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; Amino-PEG7-acid; NH2-PEG7-COOH; Amine-PEG7-acetic acid; α-Amino-ω-carboxy heptaethylene glycol; H2N-PEG7-CH2COOH; 8-Aza-3,6,9,12,15,18,21-heptaoxatricosanoic acid
EINECS	Contact for details

Quality Control

Our H2N-Peg7-Ch2Cooh is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Amine Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.