Description

1-Piperazinecarbonyl Chloride, 2,3-Dioxo- (9Ci) is a specialized heterocyclic building block and reactive intermediate of significant interest in advanced organic synthesis. Its core value lies in its ability to introduce the 2,3-dioxopiperazine-1-carbonyl chloride moiety, a key structural motif for constructing complex molecules with high precision. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals. Its controlled reactivity makes it a critical reagent for medicinal chemistry programs and custom synthesis projects.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, particularly those containing piperazine and diketopiperazine (DKP) scaffolds, which are prevalent in various therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific functional groups and explore new chemical space.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, where the heterocyclic core can contribute to biological activity.
• Peptidomimetic Development: Facilitates the creation of peptidomimetics and protease inhibitors by incorporating constrained diketopiperazine structures.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of high-value, complex organic molecules.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organochloride chemistry.

Basic Information

Item	Detail
Product Name	1-Piperazinecarbonyl Chloride, 2,3-Dioxo- (9Ci)
CAS No.	176701-73-8
Molecular Formula	C5H5ClN2O3
Molecular Weight	176.56 g/mol
Synonyms	2,3-Dioxopiperazine-1-carbonyl chloride; 1-Carbamoyl-2,3-dioxopiperazine chloride; 2,3-Diketopiperazine-1-carbonyl chloride; 1-(Chlorocarbonyl)-2,3-dioxopiperazine; 2,3-Dioxo-1-piperazinecarbonyl chloride; Piperazine-1-carbonyl chloride, 2,3-dioxo-; 176701-73-8
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarbonyl Chloride, 2,3-Dioxo- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.