Description

3S,4R-4-[Phenyl-1-Methylpiperidinyl] Methanol is a high-purity chiral piperidine derivative, a key synthetic intermediate in modern pharmaceutical development. Its precise stereochemistry is critical for imparting specific biological activity and selectivity in final active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex drug candidates targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of advanced drug candidates, especially in neurological and psychiatric therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs where the 3S,4R stereochemistry is required for efficacy.
• Asymmetric Catalysis Research: Serves as a valuable ligand precursor or chiral auxiliary in the development of new asymmetric synthetic methodologies.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies and the creation of novel compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Used in the optimization and commercial-scale manufacturing of chiral pharmaceuticals.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	3S,4R-4-[Phenyl-1-Methylpiperidinyl] Methanol
CAS No.	176022-03-0
Molecular Formula	C13H19NO
Molecular Weight	205.30 g/mol
Synonyms	(3S,4R)-4-(Phenyl-1-methylpiperidinyl)methanol; (3S,4R)-4-(Phenyl-1-methyl-1-piperidinyl)methanol; 1-Methyl-4-phenyl-3-piperidinemethanol (3S,4R)-; (3S,4R)-1-Methyl-4-phenyl-3-piperidinemethanol; 3S,4R-1-Methyl-4-phenyl-3-piperidinemethanol; 3S,4R-4-(Phenyl-1-methylpiperidinyl)methanol; 176022-03-0; (3S,4R)-4-(Phenyl-1-methylpiperidin-4-yl)methanol
EINECS	Contact for details

Quality Control

Our 3S,4R-4-[Phenyl-1-Methylpiperidinyl] Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S,4R isomer)
Related Substances (HPLC)	Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.