Description

3R,4S-4-[Phenyl-1-Methylpiperidinyl] Methanol is a high-purity chiral piperidine derivative, a crucial building block in advanced organic synthesis. Its defined stereochemistry makes it an essential intermediate for creating enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active pharmaceutical ingredients (APIs) and other high-value specialty molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and receptor-targeted therapies.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis: Serves as a precursor or ligand in catalytic systems for stereoselective chemical transformations.
• Fine Chemical Synthesis: Building block for complex natural products, flavors, and fragrances requiring specific stereochemical configurations.
• Academic & R&D: A valuable reference standard and starting material for medicinal chemistry and synthetic methodology research in university and corporate labs.

Basic Information

Product Name	3R,4S-4-[Phenyl-1-Methylpiperidinyl] Methanol
CAS No.	176022-02-9
Molecular Formula	C13H19NO
Molecular Weight	205.30 g/mol
Synonyms	(3R,4S)-4-(Phenyl-1-methylpiperidinyl)methanol; (3R,4S)-4-(Phenyl-1-methyl-1-piperidinyl)methanol; 1-Methyl-4-(phenyl)-4-piperidinemethanol (3R,4S)-; 4-(Phenyl-1-methylpiperidin-4-yl)methanol (3R,4S)-; 176022-02-9; (3R,4S)-4-(Phenyl(methyl)amino)-1-piperidineethanol (related structure); 4-Piperidinemethanol, 1-methyl-4-phenyl-, (3R,4S)-
EINECS	Contact for details

Quality Control

Our 3R,4S-4-[Phenyl-1-Methylpiperidinyl] Methanol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.