Description

4-Cyano-2-Fluorobenzoyl Chloride is a high-value, multi-functional aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 4-cyano-2-fluorobenzoyl moiety, a key structural motif for modulating biological activity and material properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific fluorinated and cyano-substituted aromatic systems.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating fluorinated and cyano-containing molecules used in electronic display technologies.
• Polymer Modification: Employed to introduce functional groups into polymer chains to alter thermal stability, solubility, or other material characteristics.
• Peptide & Protein Research: Can be used as an acylating agent for modifying amino acids or peptides in biochemical research.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex, high-performance colorants.
• Cross-Coupling Reactions: The acid chloride group facilitates its use in various metal-catalyzed coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Custom Synthesis & R&D: A versatile reagent for contract research organizations (CROs) and academic labs exploring new chemical entities.

Basic Information

Product Name	4-Cyano-2-Fluorobenzoyl Chloride
CAS No.	175596-02-8
Molecular Formula	C8H3ClFNO
Molecular Weight	183.57 g/mol
Synonyms	2-Fluoro-4-cyanobenzoyl chloride; 4-Cyano-2-fluorobenzoic acid chloride; 2-Fluoro-4-cyanobenzoic acid chloride; 4-Cyano-2-fluorobenzoic acid, chloride; Benzoic acid, 4-cyano-2-fluoro-, chloride; 4-CN-2-F-C6H3-COCl; 2-Fluoro-4-cyanobenzoyl chloride (175596-02-8)
EINECS	Contact for details

Quality Control

Our 4-Cyano-2-Fluorobenzoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive identity and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.