Description

2,5-Piperazinedione, 3,6-Bis(1H-Indol-3-Ylmethyl)-, (3R,6S)- is a specialized diketopiperazine derivative of significant interest in advanced pharmaceutical research and development. This compound, with CAS No. 175414-35-4, is valued for its unique chiral structure and indole-containing side chains, which are key pharmacophores in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive molecules, particularly for neurological and oncological targets.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block for the synthesis of complex drug candidates and peptidomimetics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting serotonin and other neurotransmitter pathways.
• Peptide Analogue Development: Acts as a constrained scaffold for creating stable peptide analogues with enhanced bioavailability and metabolic stability.
• Biochemical Probe Synthesis: Employed in the development of selective probes for studying enzyme inhibition and receptor binding.
• Academic & Institutional R&D: Utilized in university and government laboratories for fundamental research in organic synthesis and chemical biology.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development programs.

Basic Information

Product Name	2,5-Piperazinedione, 3,6-Bis(1H-Indol-3-Ylmethyl)-, (3R,6S)-
CAS No.	175414-35-4
Molecular Formula	C₂₄H₂₄N₄O₂
Molecular Weight	400.48 g/mol
Synonyms	(3R,6S)-3,6-Bis(1H-indol-3-ylmethyl)piperazine-2,5-dione; (3R,6S)-3,6-Bis(indol-3-ylmethyl)-2,5-diketopiperazine; Cyclo(L-tryptophanyl-D-tryptophanyl); D-Tryptophan, cyclic anhydride with L-tryptophan; DKP-Tryptophan Dimer; (3R,6S)-Bis(indolylmethyl)piperazinedione; (3R,6S)-3,6-Di(1H-indol-3-ylmethyl)piperazine-2,5-dione
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione, 3,6-Bis(1H-Indol-3-Ylmethyl)-, (3R,6S)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.