Description

1-Phenyl-5-(Trifluoromethyl)Pyrazole-4-Carbonyl Chloride is a high-value, reactive chemical intermediate featuring a pyrazole core with phenyl and trifluoromethyl substituents. This compound matters for its role as a versatile building block in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its acyl chloride functionality enables efficient amide bond formation and further derivatization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the trifluoromethylpyrazole moiety.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the creation of novel pyrazole-based ligands for catalytic systems and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	1-Phenyl-5-(Trifluoromethyl)Pyrazole-4-Carbonyl Chloride
CAS No.	175137-14-1
Molecular Formula	C11H6ClF3N2O
Molecular Weight	274.63 g/mol
Synonyms	1-Phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride; 5-(Trifluoromethyl)-1-phenyl-1H-pyrazole-4-carbonyl chloride; 1-Phenyl-5-trifluoromethylpyrazole-4-carboxylic acid chloride; 4-Pyrazolecarbonyl chloride, 1-phenyl-5-(trifluoromethyl)-; 175137-14-1
EINECS	Contact for details

Quality Control

Our 1-Phenyl-5-(Trifluoromethyl)Pyrazole-4-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and organic solvents. Handle in a well-ventilated area using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.