Description

4-((4-Aminophenyl)Sulfonyl)-1-(tert-Butyloxycarbonyl)Piperazine is a high-purity, protected piperazine derivative featuring both a sulfonamide and a Boc-protected amine, making it a versatile and valuable building block in advanced organic synthesis. This compound is specifically engineered to provide a reactive handle for the controlled introduction of the 4-aminophenylsulfonyl moiety while maintaining orthogonal protection for the piperazine nitrogen. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of sulfonamide-based drug candidates, including potential treatments for cancer, inflammation, and central nervous system disorders.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that leverage the sulfonamide pharmacophore.
• Chemical Biology & Proteomics: Serves as a building block for creating activity-based probes or affinity tags to study enzyme function and protein interactions.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with specific sulfonamide functionalities.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	4-((4-Aminophenyl)Sulfonyl)-1-(tert-Butyloxycarbonyl)Piperazine
CAS No.	173951-84-3
Molecular Formula	C15H23N3O4S
Molecular Weight	341.42 g/mol
Synonyms	1-Boc-4-(4-aminobenzenesulfonyl)piperazine; tert-Butyl 4-((4-aminophenyl)sulfonyl)piperazine-1-carboxylate; 4-(4-Aminobenzenesulfonyl)-1-(tert-butoxycarbonyl)piperazine; 1-N-Boc-4-(4-aminophenylsulfonyl)piperazine; 4-Aminophenylsulfonylpiperazine Boc derivative; Piperazine, 4-[(4-aminophenyl)sulfonyl]-, 1-(1,1-dimethylethyl) 1,1-dimethylethyl ester; Boc-4-(4-aminophenylsulfonyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-((4-Aminophenyl)Sulfonyl)-1-(tert-Butyloxycarbonyl)Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.