Description

tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate is a high-value, protected bicyclic diamine building block used extensively in modern organic synthesis and pharmaceutical research. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for its role in creating spirocyclic and constrained amine motifs, which are pivotal for enhancing drug-like properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of spirocyclic drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used to introduce rigid, three-dimensional diamine structures into lead compounds to improve potency, selectivity, and metabolic stability.
• Ligand Synthesis: Serves as a precursor for creating sophisticated chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require complex amine backbones.
• Peptidomimetics: Integral for designing and synthesizing peptide mimics where the spiro[5.5]undecane core provides conformational restraint.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate
CAS No.	173405-78-2
Molecular Formula	C14H26N2O2
Molecular Weight	254.37 g/mol
Synonyms	3-(tert-Butoxycarbonyl)-3,9-diazaspiro[5.5]undecane; 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate; 3-Boc-3,9-diazaspiro[5.5]undecane; Boc-3,9-diazaspiro[5.5]undecane; 1,1-Dimethylethyl 3,9-diazaspiro[5.5]undecane-3-carboxylate; 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.