Description

Pexiganan is a synthetic antimicrobial peptide (AMP) analog derived from magainin, designed for enhanced stability and broad-spectrum activity. This compound is of significant interest for its potent bactericidal properties against a wide range of pathogens, including multi-drug resistant strains. It is primarily utilized in advanced pharmaceutical research and development for novel anti-infective therapies, particularly targeting topical applications for wound and burn care.

Application

• Research and development of novel topical antimicrobial pharmaceuticals.
• Active pharmaceutical ingredient (API) in formulations for infected wound and burn treatments.
• Investigational agent in studies targeting antibiotic-resistant bacterial infections (e.g., MRSA).
• Key component in preclinical studies for dermatological and surgical site infection prevention.
• Biochemical research tool for studying the mechanism of action of antimicrobial peptides.
• Potential use in veterinary medicine for topical antimicrobial applications.

Basic Information

Product Name	Pexiganan
CAS No.	172820-23-4
Molecular Formula	C178H300N52O47
Molecular Weight	~3850.6 g/mol
Synonyms	MSI-78; Locilex; Magainin analog; Antimicrobial peptide MSI 78; Pexiganan acetate; 22-L-Lysine magainin II amide; GIGKFLKKAKKFGKAFVKILKK-NH2
EINECS	Contact for details

Quality Control

Our Pexiganan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting high standards for research and pharmaceutical development. A detailed Certificate of Analysis (COA) providing specifications for assay, related substances, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	3.0 - 8.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.