Description

Osanetant CAS NO 172734-92-8 is a selective neurokinin 3 (NK3) receptor antagonist, representing a significant class of compounds in neuropharmacology research. Its primary value lies in its role as a key research chemical for investigating the therapeutic potential of NK3 receptor modulation in various central nervous system disorders. This high-purity compound is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on novel neurological and psychiatric treatments. We supply it to meet the stringent demands of preclinical and clinical-stage development programs.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel neurokinin receptor-targeted therapies.
• Neuroscience Studies: For in vitro and in vivo research to elucidate the role of the NK3 receptor in conditions such as schizophrenia, depression, and hormone-related disorders.
• Biochemical Assay Development: Used as a ligand in receptor binding assays, high-throughput screening (HTS), and functional studies to characterize NK3 receptor activity and screen for new drug candidates.
• Metabolism and Pharmacokinetics (DMPK): Serves as a standard in analytical method development for quantifying Osanetant and its metabolites in biological matrices.
• Academic and Institutional Research: A vital tool for universities and research institutes conducting fundamental research on tachykinin signaling pathways.
• GMP Manufacturing Support: Supplied as a high-quality starting material or intermediate for cGMP-compliant production processes under appropriate quality agreements.

Basic Information

Product Name	Osanetant
CAS No.	172734-92-8
Molecular Formula	C₂₃H₂₈N₂O₃
Molecular Weight	380.48 g/mol
Synonyms	SR 142801; (S)-N-(1-(3-(1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide; (S)-N-[1-[3-[1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4-piperidinyl]-N-methylacetamide; NK3 Receptor Antagonist SR142801; SR-142,801; Osanetant [INN]; UNII-2Z2W86L0FQ
EINECS	Contact for details

Quality Control

Our Osanetant is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development with analytical data generated by validated methods, including HPLC, NMR, and MS. While typically supplied as a research-grade chemical, we can discuss custom synthesis and quality documentation to support GMP-grade requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.