Description

1,1,2-Trichloroethane (1,2,2-D3) is a deuterated isotopologue of 1,1,2-trichloroethane, where three hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This deuteration is critical for applications requiring non-interfering internal standards in mass spectrometry and for mechanistic studies in organic and analytical chemistry. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, environmental, and chemical synthesis sectors, providing unmatched precision in trace analysis and reaction pathway elucidation.

Application

• Internal Standard for GC/MS and LC/MS: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of chlorinated solvents and related compounds in complex matrices.
• Mechanistic Studies: Used as a tracer in kinetic isotope effect (KIE) studies to investigate reaction mechanisms and pathways in organic synthesis and environmental degradation.
• NMR Spectroscopy Solvent: Acts as a deuterated solvent or co-solvent in nuclear magnetic resonance (NMR) spectroscopy, particularly for samples requiring a chlorinated solvent environment.
• Pharmaceutical Impurity Profiling: Employed in the development and validation of analytical methods for detecting and quantifying genotoxic impurities and process-related contaminants.
• Environmental Analysis: Crucial for the analysis of volatile organic compounds (VOCs) and chlorinated hydrocarbons in water, soil, and air samples by advanced chromatographic techniques.
• Metabolic Research: Utilized in isotopic labeling experiments to track metabolic pathways and the fate of chemicals in biological systems.

Basic Information

Product Name	1,1,2-Trichloroethane (1,2,2-D3)
CAS No.	171086-93-4
Molecular Formula	C2D3Cl3
Molecular Weight	136.41 g/mol
Synonyms	1,1,2-Trichloroethane-d3; Ethane-d3, 1,1,2-trichloro-; [2H3]-1,1,2-Trichloroethane; Deuterated 1,1,2-Trichloroethane; 1,1,2-Trichloro-1,2,2-trideuteroethane; Trichloroethane-d3; TCE-d3
EINECS	Contact for details

Quality Control

Every batch of our 1,1,2-Trichloroethane (1,2,2-D3) is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity by GC, and specific impurity profiles. Our quality systems support compliance with cGMP and ISO 9001 standards for research and quality control use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and reactive metals. Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Recommended storage temperature is 2-8°C to maximize stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to reference spectrum
Isotopic Purity (D-atom %)	≥ 98.0%
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.1%
Residue on Evaporation	≤ 0.01%
NMR Solubility	Conforms (in specified deuterated solvent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.