Description

4-Chloro-3-Fluorophenylmagnesium Bromide is a highly reactive Grignard reagent, a critical organometallic building block for constructing complex molecular architectures. Its value lies in enabling the efficient formation of carbon-carbon bonds, specifically through nucleophilic addition to a wide range of electrophiles. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the versatile 4-chloro-3-fluorophenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring halogenated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the chlorinated and fluorinated phenyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and materials science.
• Functional Material Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: Acts as a coupling partner in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and fine chemical manufacturers producing bespoke compounds for clients.

Basic Information

Product Name	4-Chloro-3-Fluorophenylmagnesium Bromide
CAS No.	170793-00-7
Molecular Formula	C6H3BrClFMg
Molecular Weight	233.74 g/mol
Synonyms	(4-Chloro-3-fluorophenyl)magnesium bromide; 4-Chloro-3-fluoro-1-bromomagnesio-benzene; 1-Bromo-4-chloro-3-fluoro-1-magnesio-benzene; 4-Chloro-3-fluorophenylmagnesium bromide solution; Grignard reagent C6H3ClFMgBr; 3-Fluoro-4-chlorophenylmagnesium bromide; Magnesium, bromo(4-chloro-3-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorophenylmagnesium Bromide is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for your synthetic workflows. A comprehensive Certificate of Analysis (COA) detailing concentration, assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. This material is highly moisture-sensitive (hygroscopic) and typically supplied as a solution in ether or THF. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. Keep away from heat, sparks, open flames, and oxidizing agents. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.