Description

(Ar,Bs)-α-(4-Hydroxyphenyl)-β-Methyl-4-(Phenylmethyl)-1-Piperidinepropanol Maleate is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This substance matters as a sophisticated synthetic intermediate, enabling the creation of targeted therapeutic agents with specific stereochemical configurations. It is primarily needed by R&D laboratories and pharmaceutical manufacturers focused on developing novel central nervous system (CNS) and cardiovascular drugs, where its precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for CNS-targeted therapies.
• Preclinical Research: Used in pharmacological studies to investigate structure-activity relationships (SAR) and receptor binding profiles.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for method development and quality control in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in the development of enantioselective catalytic processes due to its defined stereocenters.
• Medicinal Chemistry: A scaffold for designing and optimizing new chemical entities with potential adrenergic or dopaminergic activity.

Basic Information

Product Name	(Ar,Bs)-α-(4-Hydroxyphenyl)-β-Methyl-4-(Phenylmethyl)-1-Piperidinepropanol Maleate
CAS No.	169274-78-6
Molecular Formula	C27H35NO5
Molecular Weight	453.57 g/mol
Synonyms	4-Hydroxy-α-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate (isomer); Ar-β-Methylphenethylamine derivative maleate; (R*,S*)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate; 1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, maleate (1:1); (αR,βS)-rel-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate; Frovatriptan related compound maleate salt; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (Ar,Bs isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.